The Humboldt RCMP currently have Highway 368 blocked about three kilometres north of Lake Lenore.

The crash, which appears to involve a semi and smaller sport utility vehicle occurred during the 3 o'clock hour Wednesday afternoon.

The Humboldt Fire Department as well as Humboldt Ambulance Services responded, two people were taken to hospital with undisclosed injuries via ground ambulance.

STARS air ambulance was called but they couldn't assist due to the weather.

The RCMP are awaiting a traffic reconstructionist, they will notify the media when the road reopens, they expect that to be sometime Wednesday evening.